Can Neuroscience Help Predict Future Antisocial Behavior?

Part I of this Article reviews the tools currently available to predict antisocial behavior. Part II discusses legal precedent regarding the use of, and challenges to, various prediction methods. Part III introduces recent neuroscience work in this area and reviews two studies that have successfully used neuroimaging techniques to predict recidivism. Part IV discusses some criticisms that are commonly levied against the various prediction methods and highlights the disparity between the attitudes of the scientific and legal communities toward risk assessment generally and neuroscience specifically. Lastly, Part V explains why neuroscience methods will likely continue to help inform and, ideally, improve the tools we use to help assess, understand, and predict human behavior

Control of Stress-Induced Persistent Anxiety by an Extra-Amygdala Septohypothalamic Circuit

The extended amygdala has dominated research on the neural circuitry of fear and anxiety, but the septohippocampal axis also plays an important role. The lateral septum (LS) is thought to suppress fear and anxiety through its outputs to the hypothalamus. However, this structure has not yet been dissected using modern tools. The type 2 CRF receptor (Crfr2) marks a subset of LS neurons whose functional connectivity we have investigated using optogenetics. Crfr2^+ cells include GABAergic projection neurons that connect with the anterior hypothalamus. Surprisingly, we find that these LS outputs enhance stress-induced behavioral measures of anxiety. Furthermore, transient activation of Crfr2^+ neurons promotes, while inhibition suppresses, persistent anxious behaviors. LS Crfr2^+ outputs also positively regulate circulating corticosteroid levels. These data identify a subset of LS projection neurons that promote, rather than suppress, stress-induced behavioral and endocrinological dimensions of persistent anxiety states and provide a cellular point of entry to LS circuitry

The ACS Survey Of Globular Clusters. V. Generating A Comprehensive Star Catalog For Each Cluster

The ACS Survey of Globular Clusters has used Hubble Space Telescope's Wide-Field Channel to obtain uniform imaging of 65 of the nearest globular clusters to provide an extensive homogeneous data set for a broad range of scientific investigations. The survey goals required not only a uniform observing strategy, but also a uniform reduction strategy. To this end, we designed a sophisticated software program to process the cluster data in an automated way. The program identifies stars simultaneously in the multiple dithered exposures for each cluster and measures them using the best available point-spread function models. We describe here in detail the program's rationale, algorithms, and output. The routine was also designed to perform artificial-star tests, and we ran a standard set of similar to 10(5) tests for each cluster in the survey. The catalog described here will be exploited in a number of upcoming papers and will eventually be made available to the public via the World Wide Web.Astronom

The ACS survey of globular clusters. XIII. Photometric calibration in comparison with Stetson standards

In this study we compare the photometric data of 34 Milky Way globular clusters, observed within the ACS Treasury Program (PI: Ata Sarajedini) with the corresponding ground-based data, provided by the Photometric Standard Field Catalogs of Stetson (2000, 2005). We focus on the transformation between the HST/ACS F606W to V-band and F814W to I-band only. The goal is to assess the validity of the filter transformation equations by Sirianni et al.(2005) with respect to their dependence on metallicity, Horizontal Branch morphology, mass and integrated (V-I) colour of the various globular clusters. Such a dependence is expected due to the fact that the transformation equations are based on the observations of only one globular cluster, i.e., NGC 2419. Surprisingly, the correlation between offset and metallicity is found to be weak, with a low level significance. The correlation between offset and Horizontal Branch structure, as well as total cluster mass is still weaker. Based on the available data we do not find the photometric offset to be linked to multiple stellar populations, e.g., as found in NGC 0288, NGC 1851, and NGC 5139. The results of this study show that there are small systematic offsets between the transformed ACS- and observed ground based photometry, and that these are only weakly correlated, if at all, with various cluster parameters and their underlying stellar populations. As a result, investigators wishing to transform globular cluster photometry from the Sirianni et al.(2005) ground-based V, I system onto the Stetson (2000) system simply need to add 0.040 (+/-0.012) to the V-band magnitudes and 0.047 (+/-0.011) to the I-band magnitudes. This in turn means that the transformed ACS (V-I) colours match the ground-based values from Stetson (2000) to within ~0.01 mag.Comment: 28 pages, 14 figures, accepted for publication in ApJ

The ACS Survey Of Galactic Globular Clusters. VI. NGC 6366: A Heavily Stripped Galactic Globular Cluster

We have used observations obtained as part of the Hubble Space Telescope/ACS Survey of Galactic globular clusters (GCs) to construct a color-magnitude diagram for the bulge cluster, NGC 6366. The luminosity function derived from those data extends to M(F606W) similar to 9, or masses of similar to 0.3 M(circle dot). Unlike most GCs, the mass function peaks near the main-sequence turnoff with significantly fewer low-mass stars even after correction for completeness and mass segregation. Using a multimass King model, we extrapolate the global cluster behavior and find the global mass function to be poorly matched by a power law, with a particular deficit of stars with masses between 0.5 and 0.7 M(circle dot). We briefly discuss this interesting anomaly within the context of tidal stripping.NASA GO-10775, 5-26555Space Telescope Science InstituteInstituto de Astrofisica de Canarias P3-94Ministry of Education and Science of the Kingdom of Spain AYA-2008-67913Astronom

The ACS Survey of Galactic Globular Clusters. viii. Effects of Environment on Globular Cluster Global Mass Functions

We have used observations obtained as part of the Hubble Space Telescope/ACS Survey of Galactic Globular Clusters to construct global present-day mass functions for 17 globular clusters utilizing multi-mass King models to extrapolate from our observations to the global cluster behavior. The global present-day mass functions for these clusters are well matched by power laws from the turnoff, ≈0.8 M ☉, to 0.2-0.3 M ☉ on the lower main sequence. The slopes of those power-law fits, α, have been correlated with an extensive set of intrinsic and extrinsic cluster properties to investigate which parameters may influence the form of the present-day mass function. We do not confirm previous suggestions of correlations between α and either metallicity or Galactic location. However, we do find a strong statistical correlation with the related parameters central surface brightness, μ V , and inferred central density, ρ0. The correlation is such that clusters with denser cores (stronger binding energy) tend to have steeper mass functions (a higher proportion of low-mass stars), suggesting that dynamical evolution due to external interactions may have played a key role in determining α. Thus, the present-day mass function may owe more to nurture than to nature. Detailed modeling of external dynamical effects is therefore a requisite for determining the initial mass function for Galactic globular clusters

The ACS Survey of Galactic Globular Clusters. VI. NGC 6366: A Heavily Stripped Galactic Globular Cluster

We have used observations obtained as part of the Hubble Space Telescope/ACS Survey of Galactic globular clusters (GCs) to construct a color-magnitude diagram for the bulge cluster, NGC 6366. The luminosity function derived from those data extends to M F606W ~ 9, or masses of ~0.3 M ☉. Unlike most GCs, the mass function peaks near the main-sequence turnoff with significantly fewer low-mass stars even after correction for completeness and mass segregation. Using a multimass King model, we extrapolate the global cluster behavior and find the global mass function to be poorly matched by a power law, with a particular deficit of stars with masses between 0.5 and 0.7 M ☉. We briefly discuss this interesting anomaly within the context of tidal stripping

Suited for Success? : Suits, Status, and Hybrid Masculinity

This document is the Accepted Manuscript version. The final, definitive version of this paper has been published in Men and Masculinities, March 2017, doi: https://doi.org/10.1177/1097184X17696193, published by SAGE Publishing, All rights reserved.This article analyzes the sartorial biographies of four Canadian men to explore how the suit is understood and embodied in everyday life. Each of these men varied in their subject positions—body shape, ethnicity, age, and gender identity—which allowed us to look at the influence of men’s intersectional identities on their relationship with their suits. The men in our research all understood the suit according to its most common representation in popular culture: a symbol of hegemonic masculinity. While they wore the suit to embody hegemonic masculine configurations of practice—power, status, and rationality—most of these men were simultaneously marginalized by the gender hierarchy. We explain this disjuncture by using the concept of hybrid masculinity and illustrate that changes in the style of hegemonic masculinity leave its substance intact. Our findings expand thinking about hybrid masculinity by revealing the ways subordinated masculinities appropriate and reinforce hegemonic masculinity.Peer reviewe

Delivery of health care for cardiovascular and metabolic diseases among people living with HIV/AIDS in African countries: a systematic review protocol

Background: People living with HIV (PLHIV) in African countries are living longer due to the rollout of antiretroviral drug therapy programs, but they are at increasing risk of non-communicable diseases (NCDs). However, there remain many gaps in detecting and treating NCDs in African health systems, and little is known about how NCDs are being managed among PLHIV. Developing integrated chronic care models that effectively prevent and treat NCDs among PLHIV requires an understanding of the current patterns of care delivery and the major barriers and facilitators to health care. We present a systematic review protocol to synthesize studies of healthcare delivery for an important subset of NCDs, cardiovascular and metabolic diseases (CMDs), among African PLHIV. Methods/design: We plan to search electronic databases and reference lists of relevant studies published in African settings from January 2003 to the present. Studies will be considered if they address one or both of our major objectives and focus on health care for one or more of six interrelated CMDs (ischemic heart disease, stroke, heart failure, hypertension, diabetes, and hyperlipidemia) in PLHIV. Our first objective will be to estimate proportions of CMD patients along the “cascade of care”—i.e., screened, diagnosed, aware of the diagnosis, initiated on treatment, adherent to treatment, and with controlled disease. Our second objective will be to identify unique barriers and facilitators to health care faced by PLHIV in African countries. For studies deemed eligible for inclusion, we will assess study quality and risk of bias using previously published criteria. We will extract study data using standardized instruments. We will meta-analyze quantitative data at each level of the cascade of care for each CMD (first objective). We will use meta-synthesis techniques to understand and integrate qualitative data on health-related behaviors (second objective). Discussion: CMDs and other NCDs are becoming major health concerns for African PLHIV. The results of our review will inform the development of research into chronic care models that integrate care for HIV/AIDS and CMDs among PLHIV. Our findings will be highly relevant to health policymakers, administrators, and practitioners in African settings

A dual role for prediction error in associative learning

Confronted with a rich sensory environment, the brain must learn statistical regularities across sensory domains to construct causal models of the world. Here, we used functional magnetic resonance imaging and dynamic causal modeling (DCM) to furnish neurophysiological evidence that statistical associations are learnt, even when task-irrelevant. Subjects performed an audio-visual target-detection task while being exposed to distractor stimuli. Unknown to them, auditory distractors predicted the presence or absence of subsequent visual distractors. We modeled incidental learning of these associations using a Rescorla--Wagner (RW) model. Activity in primary visual cortex and putamen reflected learning-dependent surprise: these areas responded progressively more to unpredicted, and progressively less to predicted visual stimuli. Critically, this prediction-error response was observed even when the absence of a visual stimulus was surprising. We investigated the underlying mechanism by embedding the RW model into a DCM to show that auditory to visual connectivity changed significantly over time as a function of prediction error. Thus, consistent with predictive coding models of perception, associative learning is mediated by prediction-error dependent changes in connectivity. These results posit a dual role for prediction-error in encoding surprise and driving associative plasticity